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GIP is the main incretin hormone in healthy people, causative of most the incretin effects, but the insulin response after GIP secretion in type 2 diabetes mellitus (T2DM) is strongly reduced

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Yes, informing your primary care doctor or endocrinologist is important so they can monitor your TSH levels and adjust levothyroxine dosing if needed as weight loss progresses

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Glutathione is also involved in the transport of amino acids across cell membranes